The San Diego Zoo is located in Balboa Park, just north of downtown San Diego.
From the NORTH: From Interstate 5 (LA and Orange County), take the Pershing Drive exit and follow the signs. From Interstate 15 (Escondido and Riverside), take State Route 163 south to the Park Blvd./I-5 South exit. Exit at Park Blvd. Turn left on Park Blvd. and head north; Zoo enterance is off Park Blvd. at Zoo Place.
From the SOUTH (northbound): From Interstate 5 (Mexico), take the State Route 163 north exit, then the Zoo/Museums (Richmond Street) exit and follow the signs.
From the NORTH: From Interstate 5 (Orange County, LA), take the 78 East exit at Oceanside, proceed east to Interstate 15 South, exit at Via Rancho Parkway (Exit 27) and follow the signs to the Park. From Interstate 15 (Riverside), exit at Via Rancho Parkway (Exit 27) and follow the signs east to the Park.
From the South (northbound): From Route 163 (downtown San Diego, Mission Valley) proceed to Interstate 15 North to the Via Rancho Parkway exit (Exit 27). Go east and follow signs to the Park. From Interstate 5 or 805 (Mexico), proceed to State Route 163, then to Interstate 15 North, and then exit at Via Rancho Parkway (Exit 27). Follow signs east.